CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease E inhibitor RraA/RraA-like
Functional Family

Enzyme Information

4.1.1.112
Oxaloacetate decarboxylase.
based on mapping to UniProt P9WGY3
Oxaloacetate = pyruvate + CO(2).
-!- The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn(2+), while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg(2+). -!- Unlike EC 7.2.4.2, there is no evidence of the enzyme's involvement in Na(+) transport. -!- Formerly EC 4.1.1.3.
4.1.3.17
4-hydroxy-4-methyl-2-oxoglutarate aldolase.
based on mapping to UniProt P9WGY3
(1) 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. (2) 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate.
-!- This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate. -!- The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2- oxoglutarate to glyoxylate and pyruvate, and also catalyzes the reaction of EC 4.1.1.3.

UniProtKB Entries (1)

P9WGY3
RRAAH_MYCTU
Mycobacterium tuberculosis H37Rv
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

PDB Structure

PDB 1NXJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis
Johnston, J.M., Arcus, V.L., Morton, C.J., Parker, M.W., Baker, E.N.
J.Bacteriol.