CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.260 | 434 Repressor (Amino-terminal Domain) |
|
1.10.260.60 |
Domain Context
CATH Clusters
| Superfamily | 1.10.260.60 |
| Functional Family | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
Enzyme Information
| 2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
| Q8TEK3 |
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific
|
PDB Structure
| PDB | 1NW3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
Cell(Cambridge,Mass.)
|