CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.2.1.10
Acetaldehyde dehydrogenase (acetylating).
based on mapping to UniProt Q52060
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.
-!- Also acts, more slowly, on glycolaldehyde, propanal and butanal. -!- In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87. -!- Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. -!- NADP(+) can replace NAD(+) but the rate of reaction is much slower.

UniProtKB Entries (1)

P51016
HOA_PSEUF
Pseudomonas sp. CF600
4-hydroxy-2-oxovalerate aldolase

PDB Structure

PDB 1NVM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a bifunctional aldolase-dehydrogenase: Sequestering a reactive and volatile intermediate
Manjasetty, A.B., Powlowski, J., Vrielink, A.
Proc.Natl.Acad.Sci.USA