CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 4-hydroxy-2-oxovalerate aldolase |
Enzyme Information
| 4.1.3.39 |
4-hydroxy-2-oxovalerate aldolase.
based on mapping to UniProt P51016
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.
-!- The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH. -!- In some bacterial species, the enzyme forms a bifunctional complex with EC 1.2.1.10. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43.
|
UniProtKB Entries (1)
| P51016 |
HOA_PSEUF
Pseudomonas sp. CF600
4-hydroxy-2-oxovalerate aldolase
|
PDB Structure
| PDB | 1NVM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of a bifunctional aldolase-dehydrogenase: Sequestering a
reactive and volatile intermediate
Proc.Natl.Acad.Sci.USA
|