CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P39462
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P39462
ADH_SACS2
Saccharolobus solfataricus P2
NAD-dependent alcohol dehydrogenase

PDB Structure

PDB 1NTO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity.
Esposito, L., Bruno, I., Sica, F., Raia, C.A., Giordano, A., Rossi, M., Mazzarella, L., Zagari, A.
Febs Lett.