CATH Classification

Domain Context

CATH Clusters

Superfamily Spermadhesin, CUB domain
Functional Family mannan-binding lectin serine protease 1 isoform X1

Enzyme Information

3.4.21.104
Mannan-binding lectin-associated serine protease-2.
based on mapping to UniProt Q9JJS8
Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
-!- Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement. -!- Displays C1s-like esterolytic activity (cf. EC 3.4.21.42). -!- It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

Q9JJS8
MASP2_RAT
Rattus norvegicus
Mannan-binding lectin serine protease 2

PDB Structure

PDB 1NT0
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
Feinberg, H., Uitdehaag, J.C.M., Davies, J.M., Wallis, R., Drickamer, K., Weis, W.I.
Embo J.