CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family DNA-directed DNA polymerase

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P04415
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P04415

UniProtKB Entries (1)

P04415
DPOL_BPT4
Escherichia virus T4
DNA-directed DNA polymerase

PDB Structure

PDB 1NOZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions.
Wang, J., Yu, P., Lin, T.C., Konigsberg, W.H., Steitz, T.A.
Biochemistry