CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P23919
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

P23919
KTHY_HUMAN
Homo sapiens
Thymidylate kinase

PDB Structure

PDB 1NMX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Biochemistry