CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Glycine N-methyltransferase

Enzyme Information

2.1.1.20
Glycine N-methyltransferase.
based on mapping to UniProt P13255
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.

UniProtKB Entries (1)

P13255
GNMT_RAT
Rattus norvegicus
Glycine N-methyltransferase

PDB Structure

PDB 1NBH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Catalytic mechanism of glycine N-methyltransferase
Takata, Y., Huang, Y., Komoto, J., Yamada, T., Konishi, K., Ogawa, H., Gomi, T., Fujioka, M., Takusagawa, F.
Biochemistry