CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

Enzyme Information

1.3.1.104
Enoyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt Q8WZM3
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- The enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. -!- This entry stands for enzymes whose stereo-specificity with respect to NADP(+) is not known (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9).

UniProtKB Entries (1)

Q8WZM3
ETR1_CANTR
Candida tropicalis
Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

PDB Structure

PDB 1N9G
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers.
Torkko, J.M., Koivuranta, K.T., Kastaniotis, A.J., Airenne, T.T., Glumoff, T., Ilves, M., Hartig, A., Gurvitz, A., Hiltunen, J.K.
J.Biol.Chem.