CATH Classification

Domain Context

CATH Clusters

Superfamily Polysaccharide lyase family 8-like, C-terminal
Functional Family

Enzyme Information

4.2.2.1
Hyaluronate lyase.
based on mapping to UniProt Q54873
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.

UniProtKB Entries (1)

Q54873
HYSA_STRPN
Streptococcus pneumoniae TIGR4
Hyaluronate lyase

PDB Structure

PDB 1N7R
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The function of hydrophobic residues in the catalytic cleft of Streptococcus pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
Nukui, M., Taylor, K.B., McPherson, D.T., Shigenaga, M., Jedrzejas, M.J.
J.Biol.Chem.