CATH Classification

Domain Context

CATH Clusters

Superfamily Terpene synthase, N-terminal domain
Functional Family Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.116
(+)-camphene synthase.
based on mapping to UniProt O81192
Geranyl diphosphate = (+)-camphene + diphosphate.
-!- Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- camphene and (+)-alpha-pinene. -!- (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. -!- See also EC 4.2.3.121.
4.2.3.121
(+)-alpha-pinene synthase.
based on mapping to UniProt O81192
Geranyl diphosphate = (+)-alpha-pinene + diphosphate.
-!- Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene. -!- (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. -!- The 4-pro-R hydrogen of geranyl diphosphate is lost. -!- With synthase II of Pinus taeda (loblolly pine) (+)-beta-pinene was the only product. -!- See also EC 4.2.3.122 and EC 4.2.3.116.
5.5.1.8
(+)-bornyl diphosphate synthase.
based on mapping to UniProt O81192
Geranyl diphosphate = (+)-bornyl diphosphate.
-!- The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro. -!- The reaction proceeds via isomeration of geranyl diphosphate to (3R)- linalyl diphosphate. -!- The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate. -!- cf. EC 5.5.1.22.

UniProtKB Entries (1)

O81192
BPPS_SALOF
Salvia officinalis
(+)-bornyl diphosphate synthase, chloroplastic

PDB Structure

PDB 1N24
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase
Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B., Christianson, D.W.
Proc.Natl.Acad.Sci.USA