CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family

Enzyme Information

3.4.11.5
Prolyl aminopeptidase.
based on mapping to UniProt P96084
Release of N-terminal proline from a peptide.
-!- Present in the cytosol of mammalian and microbial cells. -!- In contrast to the mammalian form, the bacterial form of the enzyme hydrolyzes both polyproline and prolyl-2-naphthylamide. -!- The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1. -!- Belongs to peptidase family S33. -!- Formerly EC 3.4.1.4.

UniProtKB Entries (1)

P96084
PIP_THEAC
Thermoplasma acidophilum DSM 1728
Proline iminopeptidase

PDB Structure

PDB 1MU0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism
Goettig, P., Groll, M., Kim, J.-S., Huber, R., Brandstetter, H.
Embo J.