CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic domain N
Functional Family Sodium/potassium-transporting ATPase subunit alpha

Enzyme Information

7.2.2.13
Na(+)/K(+)-exchanging ATPase.
based on mapping to UniProt P06685
ATP + H(2)O + Na(+)(Side 1) + K(+)(Side 2) = ADP + phosphate + Na(+)(Side 2) + K(+)(Side 1).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed. -!- It is involved in generating the plasma membrane electrical potential. -!- Formerly EC 3.6.1.37 and EC 3.6.3.9.

UniProtKB Entries (1)

P06685
AT1A1_RAT
Rattus norvegicus
Sodium/potassium-transporting ATPase subunit alpha-1

PDB Structure

PDB 1MO8
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase
Hilge, M., Siegal, G., Vuister, G.W., Guentert, P., Gloor, S.M., Abrahams, J.P.
Nat.Struct.Biol.