CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione S-transferase A4

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P10648
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P10648
GSTA2_MOUSE
Mus musculus
Glutathione S-transferase A2

PDB Structure

PDB 1ML6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Residues 207, 216, and 221 and the catalytic activity of mGSTA1-1 and mGSTA2-2 toward benzo[a]pyrene-(7R,8S)-diol-(9S,10R)-epoxide
Gu, Y., Xiao, B., Wargo, H.L., Bucher, M.H., Singh, S.V., Ji, X.
Biochemistry