CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family Enoyl-CoA hydratase, mitochondrial

Enzyme Information

4.2.1.17
Enoyl-CoA hydratase.
based on mapping to UniProt P14604
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

UniProtKB Entries (1)

P14604
ECHM_RAT
Rattus norvegicus
Enoyl-CoA hydratase, mitochondrial

PDB Structure

PDB 1MJ3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Stereoselectivity of Enoyl-CoA Hydratase Results from Preferential Activation of One of Two Bound Substrate Conformers
Bell, A.F., Feng, Y., Hofstein, H.A., Parikh, S., Wu, J., Rudolph, M.J., Kisker, C., Whitty, A., Tonge, P.J.
Chem.Biol.