CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q03526
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q03526
ITK_MOUSE
Mus musculus
Tyrosine-protein kinase ITK/TSK

PDB Structure

PDB 1LUN
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Mallis, R.J., Brazin, K.N., Fulton, D.B., Andreotti, A.H.
Nat.Struct.Biol.