CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family NADPH-ferredoxin reductase FprA

Enzyme Information

1.18.1.2
Ferredoxin--NADP(+) reductase.
based on mapping to UniProt P9WIQ3
2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH.
-!- In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe- 2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin. -!- Formerly EC 1.6.7.1 and EC 1.6.99.4.

UniProtKB Entries (1)

P9WIQ3
FPRA_MYCTU
Mycobacterium tuberculosis H37Rv
NADPH-ferredoxin reductase FprA

PDB Structure

PDB 1LQU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase.
Bossi, R.T., Aliverti, A., Raimondi, D., Fischer, F., Zanetti, G., Ferrari, D., Tahallah, N., Maier, C.S., Heck, A.J.R., Rizzi, M., Mattevi, A.
Biochemistry