CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.170.10
Functional Family

Enzyme Information

3.4.24.27
Thermolysin.
based on mapping to UniProt P00800
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (1)

P00800
THER_BACTH
Bacillus thermoproteolyticus
Thermolysin

PDB Structure

PDB 1LNF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of zinc substitutions in the active site of thermolysin.
Holland, D.R., Hausrath, A.C., Juers, D., Matthews, B.W.
Protein Sci.