CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00344
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00344
LDH_GEOSE
Geobacillus stearothermophilus
L-lactate dehydrogenase

PDB Structure

PDB 1LDN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution.
Wigley, D.B., Gamblin, S.J., Turkenburg, J.P., Dodson, E.J., Piontek, K., Muirhead, H., Holbrook, J.J.
J.Mol.Biol.