CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.180 | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 |
|
3.10.180.10 | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 |
| Functional Family |
Enzyme Information
| 1.13.11.39 |
Biphenyl-2,3-diol 1,2-dioxygenase.
based on mapping to UniProt P17297
Biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate.
-!- This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyzes the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56. -!- The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently. -!- The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol. -!- The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2- dihydroxydibenzofuran and 1,2-dihydroxynaphthalene. -!- The enzyme is strongly inhibited by the substrate. -!- Not identical with EC 1.13.11.2.
|
UniProtKB Entries (1)
| P17297 |
BPHC_PSES1
Pseudomonas sp. KKS102
Biphenyl-2,3-diol 1,2-dioxygenase
|
PDB Structure
| PDB | 1KWB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structures of the Reaction Intermediate and its Homologue of an Extradiol-cleaving Catecholic Dioxygenase
J.Mol.Biol.
|