CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28506
HIR2B_HIRME
Hirudo medicinalis
Hirudin-2B

PDB Structure

PDB 1KTS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of novel potent nonpeptide thrombin inhibitors.
Hauel, N.H., Nar, H., Priepke, H., Ries, U., Stassen, J.M., Wienen, W.
J.Med.Chem.