CATH Classification

Domain Context

CATH Clusters

Superfamily Hypothetical protein; domain 2
Functional Family N-glycosylase/DNA lyase isoform X2

Enzyme Information

3.2.2.-
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt O15527
4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt O15527
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

O15527
OGG1_HUMAN
Homo sapiens
N-glycosylase/DNA lyase

PDB Structure

PDB 1KO9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase.
Bjoras, M., Seeberg, E., Luna, L., Pearl, L.H., Barrett, T.E.
J.Mol.Biol.