CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.120.200
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P0C6E9
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P0C6E9
NANH_VIBCH
Vibrio cholerae O1 biovar El Tor str. N16961
Sialidase

PDB Structure

PDB 1KIT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Vibrio cholerae neuraminidase reveals dual lectin-like domains in addition to the catalytic domain.
Crennell, S., Garman, E., Laver, G., Vimr, E., Taylor, G.
Structure