CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Coagulation factor X |
Enzyme Information
| 3.4.21.6 |
Coagulation factor Xa.
based on mapping to UniProt P00743
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (2)
| P17726 |
TAP_ORNMO
Ornithodoros moubata
Tick anticoagulant peptide
|
| P00743 |
FA10_BOVIN
Bos taurus
Coagulation factor X
|
PDB Structure
| PDB | 1KIG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Saccharomyces |
| Primary Citation |
Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa.
J.Mol.Biol.
|