CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family calpain-2 catalytic subunit

Enzyme Information

3.4.22.53
Calpain-2.
based on mapping to UniProt P17655
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

P17655
CAN2_HUMAN
Homo sapiens
Calpain-2 catalytic subunit

PDB Structure

PDB 1KFX
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Strobl, S., Fernandez-Catalan, C., Braun, M., Huber, R., Masumoto, H., Nakagawa, K., Irie, A., Sorimachi, H., Bourenkow, G., Bartunik, H., Suzuki, K., Bode, W.
Proc.Natl.Acad.Sci.USA