CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family Glyceraldehyde-3-phosphate dehydrogenase

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt P22513
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (1)

P22513
G3PG_TRYCR
Trypanosoma cruzi
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

PDB Structure

PDB 1K3T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase complexed with chalepin, a natural product inhibitor, at 1.95 A resolution.
Pavao, F., Castilho, M.S., Pupo, M.T., Dias, R.L., Correa, A.G., Fernandes, J.B., da Silva, M.F., Mafezoli, J., Vieira, P.C., Oliva, G.
FEBS Lett.