CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family Purine nucleoside phosphorylase

Enzyme Information

2.4.2.28
S-methyl-5'-thioadenosine phosphorylase.
based on mapping to UniProt Q13126
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha- D-ribose 1-phosphate.
-!- Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups.

UniProtKB Entries (1)

Q13126
MTAP_HUMAN
Homo sapiens
S-methyl-5'-thioadenosine phosphorylase

PDB Structure

PDB 1K27
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
Singh, V., Shi, W., Evans, G.B., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
Biochemistry