CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1190.20
Functional Family Phosphomethylpyrimidine kinase ThiD

Enzyme Information

2.7.4.7
Phosphooxymethylpyrimidine kinase.
based on mapping to UniProt P55882
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2- methyl-5-(diphosphooxymethyl)pyrimidine.
2.7.1.49
Hydroxymethylpyrimidine kinase.
based on mapping to UniProt P55882
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2- methyl-5-(phosphomethyl)pyrimidine.
-!- CTP, UTP and GTP can act as donors.

UniProtKB Entries (1)

P55882
THID_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

PDB Structure

PDB 1JXI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Cheng, G., Bennett, E.M., Begley, T.P., Ealick, S.E.
Structure