CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.1
Purine-nucleoside phosphorylase.
based on mapping to UniProt P50389
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.
2.4.2.28
S-methyl-5'-thioadenosine phosphorylase.
based on mapping to UniProt P50389
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha- D-ribose 1-phosphate.
-!- Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups.

UniProtKB Entries (1)

P50389
PNPH_SACS2
Saccharolobus solfataricus P2
Purine nucleoside phosphorylase

PDB Structure

PDB 1JPV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
J.Biol.Chem.