CATH Classification

Domain Context

CATH Clusters

Superfamily Enolase-like, N-terminal domain
Functional Family Hydrophobic dipeptide epimerase

Enzyme Information

5.1.1.20
L-Ala-D/L-Glu epimerase.
based on mapping to UniProt O34508
L-alanyl-D-glutamate = L-alanyl-L-glutamate.
-!- The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. -!- In vitro the enzyme from E.coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from B.subtilis. -!- Formerly EC 5.1.1.n1.

UniProtKB Entries (1)

O34508
AEEP_BACSU
Bacillus subtilis subsp. subtilis str. 168
L-Ala-D/L-Glu epimerase

PDB Structure

PDB 1JPM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.
Gulick, A.M., Schmidt, D.M., Gerlt, J.A., Rayment, I.
Biochemistry