CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Estrogen sulfotransferase

Enzyme Information

2.8.2.14
Bile-salt sulfotransferase.
based on mapping to UniProt Q06520
(1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate. (2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
-!- The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species. -!- This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. -!- In addition to the 5-beta-bile acid glycolithocholate, deoxycholate, 3-beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3-beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC 2.8.2.2 and EC 2.8.2.34). -!- May be identical to EC 2.8.2.2.

UniProtKB Entries (1)

Q06520
ST2A1_HUMAN
Homo sapiens
Bile salt sulfotransferase

PDB Structure

PDB 1J99
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate.
Rehse, P.H., Zhou, M., Lin, S.X.
Biochem.J.