CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P13922
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P13922
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P13922
DRTS_PLAFK
Plasmodium falciparum K1
Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB 1J3I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Insights into antifolate resistance from malarial DHFR-TS structures.
Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M.D., Yuthavong, Y.
NAT.STRUCT.BIOL.