CATH Classification

Domain Context

CATH Clusters

Superfamily ArcTGT, C2 domain
Functional Family

Enzyme Information

2.4.2.48
tRNA-guanine(15) transglycosylase.
based on mapping to UniProt O58843
Guanine(15) in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanine(15) in tRNA + guanine.
-!- Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. -!- This archaeal enzyme catalyzes the exchange of guanine at position 15 of tRNA with the base preQ(0), which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97).

UniProtKB Entries (1)

O58843
ATGT_PYRHO
Pyrococcus horikoshii OT3
TRNA-guanine(15) transglycosylase

PDB Structure

PDB 1IT7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of archaeosine tRNA-guanine transglycosylase.
Ishitani, R., Nureki, O., Fukai, S., Kijimoto, T., Nameki, N., Watanabe, M., Kondo, H., Sekine, M., Okada, N., Nishimura, S., Yokoyama, S.
J.Mol.Biol.