CATH Classification

Domain Context

CATH Clusters

Superfamily Fructose-1,6-Bisphosphatase, subunit A, domain 1
Functional Family inositol polyphosphate 1-phosphatase

Enzyme Information

3.1.3.57
Inositol-1,4-bisphosphate 1-phosphatase.
based on mapping to UniProt P21327
1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D-myo-inositol 4-phosphate + phosphate.
-!- Acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar V(max) for both substrates, but with a 5 times higher affinity for the bisphosphate. -!- Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.

UniProtKB Entries (1)

P21327
INPP_BOVIN
Bos taurus
Inositol polyphosphate 1-phosphatase

PDB Structure

PDB 1INP
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
York, J.D., Ponder, J.W., Chen, Z.W., Mathews, F.S., Majerus, P.W.
Biochemistry