CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Enzyme Information

2.7.7.60
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
based on mapping to UniProt Q46893
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q46893
ISPD_ECOLI
Escherichia coli K-12
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

PDB Structure

PDB 1INJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
Richard, S.B., Bowman, M.E., Kwiatkowski, W., Kang, I., Chow, C., Lillo, A.M., Cane, D.E., Noel, J.P.
Nat.Struct.Biol.