CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.190.80
Functional Family

Enzyme Information

3.1.3.94
D-galactose 1-phosphate phosphatase.
based on mapping to UniProt P29218
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate.
-!- The human enzyme also has the activity of EC 3.1.3.25. -!- The enzyme has very low activity with L-galactose 1-phosphate (cf. EC 3.1.3.93).
3.1.3.25
Inositol-phosphate phosphatase.
based on mapping to UniProt P29218
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
-!- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. -!- It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols.

UniProtKB Entries (1)

P29218
IMPA1_HUMAN
Homo sapiens
Inositol monophosphatase 1

PDB Structure

PDB 1IMB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of inositol monophosphatase complexes with substrates.
Bone, R., Frank, L., Springer, J.P., Pollack, S.J., Osborne, S.A., Atack, J.R., Knowles, M.R., McAllister, G., Ragan, C.I., Broughton, H.B., Baker, R., Fletcher, S.R.
Biochemistry