CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A subunit), domain 1
Functional Family Ricin

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P02879
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P02879
RICI_RICCO
Ricinus communis
Ricin

PDB Structure

PDB 1IL5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
Miller, D.J., Ravikumar, K., Shen, H., Suh, J.K., Kerwin, S.M., Robertus, J.D.
J.Med.Chem.