CATH Classification

Domain Context

CATH Clusters

Superfamily Haem peroxidase domain superfamily, animal type
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt P05979
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

P05979
PGH1_SHEEP
Ovis aries
Prostaglandin G/H synthase 1

PDB Structure

PDB 1IGX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
Malkowski, M.G., Thuresson, E.D., Lakkides, K.M., Rieke, C.J., Micielli, R., Smith, W.L., Garavito, R.M.
J.Biol.Chem.