CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases. Chain C
Functional Family Cathepsin L1

Enzyme Information

3.4.22.15
Cathepsin L.
based on mapping to UniProt P07711
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07711
CATL1_HUMAN
Homo sapiens
Cathepsin L1

PDB Structure

PDB 1ICF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.
Guncar, G., Pungercic, G., Klemencic, I., Turk, V., Turk, D.
EMBO J.