CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36897
TGFR1_HUMAN
Homo sapiens
TGF-beta receptor type-1

PDB Structure

PDB 1IAS
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.
Huse, M., Muir, T.W., Xu, L., Chen, Y.G., Kuriyan, J., Massague, J.
Mol.Cell