CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarylacetoacetase-like, C-terminal domain
Functional Family

Enzyme Information

5.3.3.10
5-carboxymethyl-2-hydroxymuconate Delta-isomerase.
based on mapping to UniProt P37352
5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3- enedioate.
-!- Part of the homoprotocatechuate degradation pathway in Escherichia coli C.
4.1.1.68
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase.
based on mapping to UniProt P37352
(3E,5R)-5-carboxy-2-oxohept-3-enedioate = (4Z)-2-oxohept-4-enedioate + CO(2).
-!- Part of the 4-hydroxyphenylacetate degradation pathway in Escherichia coli C.

UniProtKB Entries (1)

P37352
HPCE_ECOLX
Escherichia coli
Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase

PDB Structure

PDB 1I7O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of HpcE, a multi-functional enzyme fold
Tame, J.R.H., Namba, K., Dodson, E.J., Roper, D.I.
To be Published