CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family Glyceraldehyde-3-phosphate dehydrogenase

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt Q27890
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (1)

Q27890
G3PG_LEIME
Leishmania mexicana
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

PDB Structure

PDB 1I33
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors.
Suresh, S., Bressi, J.C., Kennedy, K.J., Verlinde, C.L., Gelb, M.H., Hol, W.G.
J.Mol.Biol.