CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Thimet oligopeptidase 1

Enzyme Information

3.4.24.16
Neurolysin.
based on mapping to UniProt P42676
Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.
-!- No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. -!- Belongs to peptidase family M3.

UniProtKB Entries (1)

P42676
NEUL_RAT
Rattus norvegicus
Neurolysin, mitochondrial

PDB Structure

PDB 1I1I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of neurolysin reveals a deep channel that limits substrate access.
Brown, C.K., Madauss, K., Lian, W., Beck, M.R., Tolbert, W.D., Rodgers, D.W.
Proc.Natl.Acad.Sci.USA