CATH Classification

Domain Context

CATH Clusters

Superfamily HMGR, N-terminal domain
Functional Family 3-hydroxy-3-methylglutaryl coenzyme A reductase

Enzyme Information

1.1.1.34
Hydroxymethylglutaryl-CoA reductase (NADPH).
based on mapping to UniProt P04035
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

UniProtKB Entries (1)

P04035
HMDH_HUMAN
Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB Structure

PDB 1HWJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural mechanism for statin inhibition of HMG-CoA reductase.
Istvan, E.S., Deisenhofer, J.
Science