CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, thumb domain
Functional Family DNA polymerase beta

Enzyme Information

4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06766
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06766
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P06766
DPOLB_RAT
Rattus norvegicus
DNA polymerase beta

PDB Structure

PDB 1HUO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Arndt, J.W., Gong, W., Zhong, X., Showalter, A.K., Liu, J., Dunlap, C.A., Lin, Z., Paxson, C., Tsai, M.D., Chan, M.K.
Biochemistry