CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00735
THRB_BOVIN
Bos taurus
Prothrombin
P01050
HIRV1_HIRME
Hirudo medicinalis
Hirudin variant-1

PDB Structure

PDB 1HRT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution.
Vitali, J., Martin, P.D., Malkowski, M.G., Robertson, W.D., Lazar, J.B., Winant, R.C., Johnson, P.H., Edwards, B.F.
J.Biol.Chem.