CATH Classification

Domain Context

CATH Clusters

Superfamily Methyl-coenzyme M reductase, gamma subunit
Functional Family

Enzyme Information

2.8.4.1
Coenzyme-B sulfoethylthiotransferase.
based on mapping to UniProt P11562
Methyl-CoM + CoB = CoM-S-S-CoB + methane.
-!- This enzyme catalyzes the final step in methanogenesis, the biological production of methane. -!- This important anaerobic process is carried out only by methanogenic archaea. -!- The enzyme can also function in reverse, for anaerobic oxidation of methane. -!- The enzyme requires the hydroporphinoid nickel complex coenzyme F(430). -!- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. -!- The sulfide sulfur can be replaced by selenium but not by oxygen.

UniProtKB Entries (1)

P11562
MCRG_METTM
Methanothermobacter marburgensis str. Marburg
Methyl-coenzyme M reductase I subunit gamma

PDB Structure

PDB 1HBM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
On the Mechanism of Biological Methane Formation: Structural Evidence for Conformational Changes in Methyl-Coenzyme M Reductase Upon Substrate Binding
Grabarse, W., Mahlert, F., Duin, E.C., Goubeaud, M., Shima, S., Thauer, R.K., Lamzin, V., Ermler, U.
J.Mol.Biol.