CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Glutathione reductase, mitochondrial

Enzyme Information

1.8.1.7
Glutathione-disulfide reductase.
based on mapping to UniProt P00390
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
-!- Activity is dependent on a redox-active disulfide in each of the active centers. -!- Formerly EC 1.6.4.2.

UniProtKB Entries (1)

P00390
GSHR_HUMAN
Homo sapiens
Glutathione reductase, mitochondrial

PDB Structure

PDB 1GSN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Becker, K., Savvides, S.N., Keese, M., Schirmer, R.H., Karplus, P.A.
Nat.Struct.Biol.