CATH Classification

Domain Context

CATH Clusters

Superfamily Ureohydrolase domain
Functional Family

Enzyme Information

3.5.3.22
Proclavaminate amidinohydrolase.
based on mapping to UniProt P0DJQ3
Amidinoproclavaminate + H(2)O = proclavaminate + urea.
-!- Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. -!- It carries out an intermediary reaction between the first reaction of EC 1.14.11.21, and the second and third reactions of that enzyme.

UniProtKB Entries (1)

P0DJQ3
PAH_STRCL
Streptomyces clavuligerus
Proclavaminate amidinohydrolase

PDB Structure

PDB 1GQ7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
Elkins, J.M., Clifton, I.J., Hernandez, H., Doan, L.X., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
Biochem. J.